Copyright © Radosys Ltd. 2013
There are potential unwanted events that may provide a dosimetry laboratory or service with tasks that cannot be
covered by routine monitoring of radiation workers.
Triage at nuclear accidents or radio terrorism requires effective procedures to estimate the dose received by individuals,
or in other words by the public after the event.
Occasionally, radiation accidents happen to individuals as well when the person is not monitored, but the occurrence of
potential dose receipt is known. Examples are improper handling of medical isotopes or accidents during maintenance
works on radiology equipment. The dosimetry task is the same, - to estimate the received dose after the event to
contribute to the decisions about the appropriate treatment.
In the practice of biodosimetry the post-event dose estimation is done by evaluating the level of genetic aberrations
caused by the irradiation. One of the most effective ways is to detect disorders at the division of lymphocytes in the
blood sample. Lymphocytes are forced to divide in vitro stopping the process at the anaphase, where binucleated cells
are already seen, and at the case of genetic aberration an abnormal extra chunk of the nuclei, the so called
micronucleus is seen too. By counting the number of micronucleus the received dose is concluded.
In general, genetic aberration is produced not by radiation only, but by a wide range of chemicals or other unwanted
external influences. In general, micronucleus counting is a routine method in genotoxicology to detect material
incompatibility at pharmacology research, food processing or specific industrial technologies, like the use of
nanoparticles. The latter even has its own title, -Nanotoxicology.
The Radosys MN-series image analysis software together with the Radometer-series automated microscope form an
effective system for micronucleus counting utilizing all the features of the Radosys technologies.
covered by routine monitoring of radiation workers.
Triage at nuclear accidents or radio terrorism requires effective procedures to estimate the dose received by individuals,
or in other words by the public after the event.
Occasionally, radiation accidents happen to individuals as well when the person is not monitored, but the occurrence of
potential dose receipt is known. Examples are improper handling of medical isotopes or accidents during maintenance
works on radiology equipment. The dosimetry task is the same, - to estimate the received dose after the event to
contribute to the decisions about the appropriate treatment.
In the practice of biodosimetry the post-event dose estimation is done by evaluating the level of genetic aberrations
caused by the irradiation. One of the most effective ways is to detect disorders at the division of lymphocytes in the
blood sample. Lymphocytes are forced to divide in vitro stopping the process at the anaphase, where binucleated cells
are already seen, and at the case of genetic aberration an abnormal extra chunk of the nuclei, the so called
micronucleus is seen too. By counting the number of micronucleus the received dose is concluded.
In general, genetic aberration is produced not by radiation only, but by a wide range of chemicals or other unwanted
external influences. In general, micronucleus counting is a routine method in genotoxicology to detect material
incompatibility at pharmacology research, food processing or specific industrial technologies, like the use of
nanoparticles. The latter even has its own title, -Nanotoxicology.
The Radosys MN-series image analysis software together with the Radometer-series automated microscope form an
effective system for micronucleus counting utilizing all the features of the Radosys technologies.
Biodosimetry
